Millions of people and billions of dollars are involved in health and medical research across the globe, but it could be argued that all this investment has not transformed health care or reduced the key health problems .Expenditure of life science research in 2010 was US$240 billions with United States of America as the largest funder (US$70 billion in commercial and US$40 billions in governmental and non- profit). Chalmers and Glasziou reported that US$200 billion was wasted in 2010 out of the US$240 billions, as research finding were unusable and reports inaccessible .It is not exactly clear who is the blame, the scientists, funding agencies, governments, politicians, commercial medical companies, medical journals, editors, reviewers or institutional/government ethics committees or health-care managers.