Pseudo-CT generation from Pelvic MRI for dose calculation in radiotherapy

the aim of this project is to remove the CT acquisition and, in its place, to create pseudo-CT images based on the MRI acquisition. On the MRIdian, only one MRI sequence-type (TrueFisp) is currently available offering a mixed T2/T1 contrast. Therefore, tissue characterization is not as straightforward as with absolute T1 or T2 images (Bojorquez et al. PLoS One. 2019; 14(2)). As a first intention, the study will focus on a pelvic localization (prostate) and on a limited number of tissues such as bone, fat and soft tissue. The final purpose will be to show that the dose distribution calculation deviation between an acquired and a pseudo-CT is limited and clinically acceptable.